Legenza, LaurelCoetzee, RenierRose, Warren E.2023-06-142023-06-142022Legenza, L. et al. (2023). Application of consolidated framework for implementation research to improve Clostridioides difficile infection management in district hospitals. Research in Social and Administrative Pharmacy, 18(12), 4100-4111. https://doi.org/10.1016/j.sapharm.2022.07.0461934-8150https://doi.org/10.1016/j.sapharm.2022.07.046http://hdl.handle.net/10566/9085Clostridioides difficile infection (CDI) contributes the global threats of drug resistant infections, healthcare acquired infections and antimicrobial resistance. Yet CDI knowledge among healthcare providers in low-resource settings is limited and CDI testing, treatment, and infection prevention measures are often delayed. To develop a CDI intervention informed by the local context within South African public district level hospitals, and analyze the CDI intervention and implementation process. A CDI checklist intervention was designed and implemented at three district level hospitals in the Western Cape, South Africa that volunteered to participate. Data collection included a retrospective medical records review of patients hospitalized with C. difficile test orders during the 90 days post-implementation. Patient outcomes and checklist components (e.g. antibiotics) were collected.enPublic healthGlobal healthSouth AfricaImplementation scienceClostridioides difficile infectionArticle