Fielding, BurtramLiedeman, Kerwin2021-03-252024-11-042021-03-252024-11-042020https://hdl.handle.net/10566/17227Magister Scientiae (Medical Bioscience) - MSc(MBS)Insect-derived baculoviruses have been used extensively as a safe and versatile research model for transgenic protein expression. Preclinical studies have revealed the promising potential of Baculoviruses as a delivery vector for a variety of therapeutic applications, including vaccination, tissue engineering and cancer treatments. Coronaviruses are enveloped viruses containing linear, non-segmented ribonucleic acid. Human coronavirus NL63 was first discovered in the Netherlands in January 2004, where a 7-month-old girl presented with an acute respiratory tract infection that was later established to predominantly infect infants, the elderly and immunocompromised individuals.enHuman CoronavirusBaculovirus systemTransgenic protein expressionVirusesBacterial cell linesUniversity of Western Cape