Umar, Maimuna BelloDaniel, Augustine InnalegwuTijani, Jimoh Oladejo2023-05-292023-05-292023Umar, M. B. et al. (2023). Hypoglycaemic activity of biosynthesized copper oxide nanoparticles in alloxan-induced diabetic Wister rats. Endocrinology, Diabetes & Metabolism, 6 (3), e423. https://doi.org/10.1002/edm2.4232398-9238https://doi.org/10.1002/edm2.423http://hdl.handle.net/10566/8939Diabetes mellitus (DM) is a metabolic disorder that affects the body's ability to produce or use insulin. This study evaluated the hypoglycaemic activity of biosynthesized copper oxide nanoparticles (CuO-NPs) in alloxan-induced diabetic Wister rats. CuO-NPs were synthesized via the green route and characterized using different analytical tools. Diabetes was induced intraperitoneally using 90 mg/kg body weight of alloxan monohydrate in albino rats. Thirty (30) rats were randomly divided into 5 groups of 6 rats each and orally treated for 21 days. Groups I and II were treated with 300 mg/kg bwt Cereus hildmannianus extract and CuO-NPs, respectively. Groups III and IV received 5 mg/kg bwt of Glibenclamide and 2 mL of normal saline, respectively, while Group V was left untreated as the diabetic control. Blood glucose (BG) levels and body weight changes were monitored at 3- and 7- day intervals, respectively, throughout 21-day treatment period. Lipid profiles, enzyme assays and histopathological studies of the liver were also carried out.enBiotechnologyBiosynthesisCopper oxide nanoparticlesDabetes mellitusHistoarchitectureArticle