Egunlusi, Ayodeji, OMalan, Sarel, FJoubert, Jacques2021-09-132021-09-132020-09https://doi.org/10.24820/ark.5550190.p011.302http://hdl.handle.net/10566/6650Neurodegenerative disorders are characterised by progressive loss of neuronal functions. Of the proposed mechanisms, excitotoxicity, mediated by prolonged glutamate activation and calcium overload, is prominent. NGP1-01, a polycyclic cage amine, and tricyclo[6.2.1.02,7]undec-9-ene-3,6-dione have been shown to display calcium-modulating properties. In this study, we synthesised structurally-related 4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione as the base scaffold, and incorporated various functional moieties through aminolysis, to afford a series of imide derivatives. All final compounds were obtained in yields between 47-97% and their structures were confirmed by NMR, IR and MS. These structurally-related derivatives could potentially act as neuroprotective agents. Additionally, their synthetic versatilities could make them precursors, as lead compounds, to potential pharmacologically-active agents.en4-Oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dionecycloaddition reactionsaminolysisnorbornenesnorbornene scaffoldsneurodegenerative disordersArticle