Iwuoha, Emmanuel I.Sidwaba, Unathi2017-07-282024-05-132020-08-312024-05-132017Sidwaba, Unathi. ( 2017). Electrochemical poly(ProDOT) dendritic DNA aptamer biosensor for signalling interferon gamma (IFN-ɣ) TB biomarker. PhD. University of the Western Capehttps://hdl.handle.net/10566/14688Philosophiae Doctor - PhDTuberculosis (TB) is an infectious disease that, despite all efforts devoted towards its eradication, remains a threat to many countries including South Africa. Current diagnostic assays do offer better performance than the conventional sputum smear microscopy and tuberculin skin tests. However, these assays have been proven to be affected by various factors including the condition of an individual's immune system and vaccination history. By far, electrochemical biosensors are amongst the currently investigated techniques to address the shortcomings associated with these diagnostics.enAptasensorBisphenol AConducting polymer nanocompositesDisease biomarkerDNA aptamerElectrochemical impedance spectroscopyEndocrine disrupting compoundsGold nanoparticlesImmune systemInterferon gammaLimit of detectionPleural fluidPoly(3,4-propylenedioxythiophene)TuberculosisUniversity of the Western Cape