Titinchi, FadiBehardien, NashreenMorkel, JeanOpperman, Johan2020-10-262020-10-262020Titinchi, F . et al. (2020). Perforation of the palate - A report of two Syphilitic Gumma cases. South African Dental Journal. 75(6),309 - 313. Doi: http://dx.doi.org/10.17159/2519-0105/2020/v75no6a40375-1562http://hdl.handle.net/10566/5303Syphilis has recently shown resurgence in its incidence especially in immune-compromised patients. We present two cases of tertiary syphilis in middle-aged males with large perforations in the hard and soft palates, one of which had Human Immunodeficiency Virus (HIV) co-infection. Diagnosis was initially difficult due to non-specific features mimicking other conditions such as perforation of cocaine abuse aetiology, neoplastic conditions, sarcoidosis, fungal infections, bacterial infections other than Treponema pallidum and Wegeners granulomatosis.enOrofacial syphilisTreponema pallidumGummaOronasal fistulaArticle