Tshabalala, MqondisiIngram, CharlotteSchlaphoff, TerryBorrill, VeronicaChristoffels, AlanPepper, Michael S.2019-10-072019-10-072018Mqondisi Tshabalala, Charlotte Ingram, Terry Schlaphoff, Veronica Borrill, Alan Christoffels, and Michael S. Pepper, “Human Leukocyte Antigen-A, B, C, DRB1, and DQB1 Allele and Haplotype Frequencies in a Subset of 237 Donors in the South African Bone Marrow Registry,” Journal of Immunology Research, vol. 2018, Article ID 2031571, 8 pages, 2018. https://doi.org/10.1155/2018/2031571.2314-7156https://doi.org/10.1155/2018/2031571http://hdl.handle.net/10566/4988Human leukocyte antigen- (HLA-) A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 allele and haplotype frequencies were studied in a subset of 237 volunteer bone marrow donors registered at the South African Bone Marrow Registry (SABMR). Hapl-o-Mat software was used to compute allele and haplotype frequencies from individuals typed at various resolutions, with some alleles in multiple allele code (MAC) format. Four hundred and thirty-eight HLA-A, 235 HLA-B, 234 HLA-DRB1, 41 HLA-DQB1, and 29 HLA-C alleles are reported. The most frequent alleles were A02:02g (0.096), B07:02g (0.082), C07:02g (0.180), DQB106:02 (0.157), and DRB115:01 (0.072). The most common haplotype was A03:01g~B07:02g~C07:02g~DQB106:02~DRB115:01 (0.067), which has also been reported in other populations. Deviations from Hardy-Weinberg equilibrium were observed in A, B, and DRB1 loci, with C~DQB1 being the only locus pair in linkage disequilibrium. This study describes allele and haplotype frequencies from a subset of donors registered at SABMR, the only active bone marrow donor registry in Africa. Although the sample size was small, our results form a key resource for future population studies, disease association studies, and donor recruitment strategies.enHuman leukocyte antigen (HLA)Haplotype frequenciesDQB1 AlleleSouth African Bone Marrow RegistryArticle