DDPC: Dragon database of genes associated with prostate cancer

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dc.contributor.authorMaqungo, Monique
dc.contributor.authorKaur, Mandeep
dc.contributor.authorKwofie, Samuel K.
dc.contributor.authorRadovanovic, Aleksander
dc.contributor.authorSchaefer, Ulf
dc.contributor.authorSchmeier, Sebastian
dc.contributor.authorOppon, Ekow
dc.contributor.authorChristoffels, Alan
dc.contributor.authorBajic, Vladimir B.
dc.date.accessioned2015-10-28T14:08:38Z
dc.date.available2015-10-28T14:08:38Z
dc.date.issued2011
dc.description.abstractProstate cancer (PC) is one of the most commonly diagnosed cancers in men. PC is relatively difficult to diagnose due to a lack of clear early symptoms. Extensive research of PC has led to the availability of a large amount of data on PC. Several hundred genes are implicated in different stages of PC, which may help in developing diagnostic methods or even cures. In spite of this accumulated information, effective diagnostics and treatments remain evasive. We have developed Dragon Database of Genes associated with Prostate Cancer (DDPC) as an integrated knowledgebase of genes experimentally verified as implicated in PC. DDPC is distinctive from other databases in that (i) it provides pre-compiled biomedical text-mining information on PC, which otherwise require tedious computational analyses, (ii) it integrates data on molecular interactions, pathways, gene ontologies, gene regulation at molecular level, predicted transcription factor binding sites on promoters of PC implicated genes and transcription factors that correspond to these binding sites and (iii) it contains DrugBank data on drugs associated with PC. We believe this resource will serve as a source of useful information for research on PC.en_US
dc.description.sponsorshipDST/NRF Research Chair National Bioinformatics Network grants National Research Foundation of South Africaen_US
dc.identifier.citationBajic, V.B. et al. (2011). DDPC: Dragon Database of Genes associated with Prostate Cancer. Nucleic Acids Research 39(1): D980-D985
dc.identifier.urihttp://hdl.handle.net/10566/1930
dc.language.isoenen_US
dc.privacy.showsubmitterfalse
dc.publisherOxford Journals
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttp://dx.doi.org/10.1093/nar/gkq849
dc.status.ispeerreviewedfalse
dc.subjectProstate Canceren_US
dc.subjectDatabaseen_US
dc.subjectDrugbank dataen_US
dc.titleDDPC: Dragon database of genes associated with prostate canceren_US
dc.typeArticleen_US

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