Investigation of the Stress-Induced Nuclear Localisation of Retinoblastoma Binding Protein 6 (Rbbp6) and its Role in Ubiquitination Of Y-Box Binding Protein-1 (Yb-1)

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Date

2017

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University of the Western Cape

Abstract

Retinoblastoma Binding Protein 6 (RBBP6) is a 200 kDa RING finger-containing human protein known to serve as an E3 ubiquitin ligase, and to play a role in ubiquitination and suppression of the tumour suppressor p53. It also regulates the stability of mRNA transcripts by modulating 3'-polyadenylation.

Description

Magister Scientiae - MSc (Biotechnology)

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