Bis(ferrocenylimine)palladium(II) and platinum(II) complexes: synthesis, molecular structures and evaluation as antitumor agents

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dc.contributor.authorMotswainyana, William M.
dc.contributor.authorOnani, Martin O.
dc.contributor.authorMadiehe, Abram M.
dc.date.accessioned2014-03-31T13:37:16Z
dc.date.available2014-03-31T13:37:16Z
dc.date.issued2012
dc.description.abstractCompounds (ferrocenyl-2-furylmethyl)imine (L1), (ferrocenyl-2-thiophenemethyl)imine (L2) and (ferrocenyl-2-thiopheneethyl)imine (L3) were synthesized by condensation reactions and obtained in very good yields. Reactions of L1 – L3 with 0.5 equiv of either PdCl2(cod), PdClMe(cod) or K2[PtCl4] gave the new corresponding trans bis(ferrocenylimine)palladium(II) and platinum(II) complexes 1 – 9. The compounds were characterized by elemental analysis, IR, 1H and 13C NMR spectroscopy. The molecular structures of 3 and 6 were determined by single crystal X-ray diffraction analysis. Both structures crystallize in monoclinic P21/n space system. The coordination geometry around the palladium atom in complexes 3 and 6 exhibits a square planar geometry at the palladium atom. Complexes 1, 7 and 9 were evaluated for their cytotoxic activities against human breast (MCF-7) and human ovarian (A2780) cancer cell lines, and they exhibited low cytotoxic activities but comparable to that of cisplatin.en_US
dc.description.accreditationWeb of Scienceen_US
dc.identifier.citationMotswainyana, W.M., Onani, M.O. & Madiehe, A.M. (2012). Bis(ferrocenylimine)palladium(II) and platinum(II) complexes: synthesis, molecular structures and evaluation as antitumor agents. Polyhedron 41: 44 - 51en_US
dc.identifier.issn0277-5387
dc.identifier.urihttp://hdl.handle.net/10566/1066
dc.language.isoenen_US
dc.privacy.showsubmitterfalse
dc.publisherElsevieren_US
dc.rightsThis is the author postprint version of an article by Elsevier. The file may be freely used, provided that acknowledgement of the source is given.
dc.source.urihttp://dx.doi.org/10.1016/j.poly.2012.04.010
dc.status.ispeerreviewedtrue
dc.subjectFerrocenylimineen_US
dc.subjectPalladium
dc.subjectPlatinum
dc.subjectMolecular structures
dc.subjectCytotoxicity
dc.subjectCancer
dc.subjectCisplatin
dc.titleBis(ferrocenylimine)palladium(II) and platinum(II) complexes: synthesis, molecular structures and evaluation as antitumor agentsen_US
dc.typeArticleen_US

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