Antibacterial and anti-inflammatory effects of Syzygium jambos L. (Alston) and isolated compounds on acne vulgaris

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dc.contributor.authorSharma, Richa
dc.contributor.authorKishore, Navneet
dc.contributor.authorHussein, Ahmed
dc.date.accessioned2023-06-07T12:11:37Z
dc.date.available2023-06-07T12:11:37Z
dc.date.issued2013
dc.description.abstractAcne vulgaris is a chronic skin disorder leading to inflammation as a result of the production of reactive oxygen species due to the active involvement of Propionibacterium acnes (P. acnes) in the infection site of the skin. The current study was designed to assess the potential of the leaf extract of Syzygium jambos L. (Alston) and its compounds for antibacterial and anti-inflammatory activity against the pathogenic P. acnes. The broth dilution method was used to assess the antibacterial activity. The cytotoxicity investigation on mouse melanocyte (B16-F10) and human leukemic monocyte lymphoma (U937) cells was done using sodium 3’-[1-(phenyl amino-carbonyl)-3,4-tetrazolium]-bis-[4-methoxy-6-nitrobenzene sulfonic acid hydrate (XTT) reagent. The non-toxic concentrations of the samples was investigated for the suppression of cytokines interleukin 8 (IL 8) and tumour necrosis factor (TNF α) by testing the supernatants in the co-culture of the human U937 cells and heat killed P. acnes using enzyme immunoassay kits (ELISA). The statistical analysis was done using the Graph Pad Prism 4 program.en_US
dc.identifier.citationSharma, R. et al. (2013). Antibacterial and anti-inflammatory effects of Syzygium jambos L. (Alston) and isolated compounds on acne vulgaris. BMC Complementary Medicine and Therapies, 13, 292. https://doi.org/10.1186/1472-6882-13-292en_US
dc.identifier.issn2662-7671
dc.identifier.urihttps://doi.org/10.1186/1472-6882-13-292
dc.identifier.urihttp://hdl.handle.net/10566/9063
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.subjectChemistryen_US
dc.subjectAntibacterialen_US
dc.subjectMicroscopyen_US
dc.subjectSkin diseaseen_US
dc.subjectPropionibacterium acnesen_US
dc.titleAntibacterial and anti-inflammatory effects of Syzygium jambos L. (Alston) and isolated compounds on acne vulgarisen_US
dc.typeArticleen_US

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