The impact of Covid-19 vaccines on male semen parameters: A retrospective cohort study

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dc.contributor.authorHenkel, Ralf
dc.contributor.authorLeisegang, Kristian
dc.contributor.authorFinelli, Renata
dc.date.accessioned2023-03-16T07:40:55Z
dc.date.available2023-03-16T07:40:55Z
dc.date.issued2023
dc.description.abstractThe emergence of SARS-CoV-2 and the subsequent COVID-19 pandemic necessitated the development of adequate vaccines. Despite vaccines being demonstrated to be safe and effective for preventing severe disease and death, vaccine hesitancy remains. Reasons include concerns over adverse effects on male fertility, which have not been widely investigated. Therefore, this study is aimed at determining the impact of COVID-19 vaccination on semen parameters in a retrospective cohort study of South African males undergoing fertility assessment. The patients for this study were adult men who have previously undergone routine semen analysis for fertility assessment at Androcryos Andrology Laboratory (Johannesburg, South Africa) between March 2021 and March 2022. They also received vaccination within 3 months following a semen analysis and underwent a second semen analysis any time post-COVID-19 vaccination. From 277 records analysed, 46 patients met the inclusion criteria, receiving the Pfizer-BioNTech (BNT162b1) (63%), Johnson and Johnson (JNJ-78436735/Ad26.COV2S) (34.8%), and the AstraZeneca (AZD1222) (2.2%) vaccines. Sperm concentration significantly increased postvaccination (P = 0:0001), with no significant changes in semen pH, volume, total sperm count, progressive motility, normal sperm morphology, or chromatin condensation. Results were not influenced by age, type of vaccine received, and the number of days following vaccination, as depicted by multiple regression analysis. In conclusion, there is no evidence of a negative impact of COVID-19 vaccination on male semen parameters, which is consistent with the emerging literature on COVID-19 vaccination and male fertility. COVID-19 vaccinations should not be dismissed based on fear of adverse effects on male fertility parameters.en_US
dc.identifier.citationLeisegang, K., Finelli, R., Moungala, L., Moichela, F., Pearce, K., Ramasamy, R. and Henkel, R., 2023. The Impact of COVID-19 Vaccines on Male Semen Parameters: A Retrospective Cohort Study. Andrologia, 2023.en_US
dc.identifier.otherhttps://doi.org/10.1155/2023/7826568
dc.identifier.urihttp://hdl.handle.net/10566/8597
dc.language.isoenen_US
dc.publisherUniversity of the Western Capeen_US
dc.subjectSouth Africaen_US
dc.subjectandrocryos andrology laboratoryen_US
dc.subjectCovid-19en_US
dc.subjectVaccinesen_US
dc.subjectMale fertilityen_US
dc.subjectAndrologyen_US
dc.titleThe impact of Covid-19 vaccines on male semen parameters: A retrospective cohort studyen_US
dc.typeArticleen_US

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