Browsing by Author "Upton, Edward"

Now showing 1 - 4 of 4
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    Allergic rhinitis: To sneeze or to wheeze. Pollen is the question, what is the answer?
    (Medpharm Publications, 2018) Martin, Bjorn; Wehmeyer, Alexander; Upton, Edward
    Allergic rhinitis, also known colloquially as hay fever, is the most common among the allergic diseases. Recent literature reports that it affects up to a tenth of the world population. Atopic diseases have a particularly high prevalence in young children which is often attributed to their immature immune systems. Traditionally, atopic diseases have plagued industrialised countries, but the burden has recently extended its reach to developing countries. Over the past few decades, there has been a marked increase in all allergy-related diseases. Supported by the advent of the Atopic March, research has been primarily directed at understanding the aetiology and pathophysiology associated with diseases stemming from atopy. In this article, we review current treatments available in South Africa and explain the pathophysiology of allergic rhinitis.
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    A comparison between estimated renal function from point-of care derived cystatin c measurements and serum creatinine derived measurements
    (University of the Western Cape, 2022) Mogakane, Khomotso Lesedi; Upton, Edward
    Serum Creatinine (SCr) is the most commonly used and cost effective biomarker used to quantify estimated glomerular filtration rate. However, creatinine is affected by anthropometric parameters such as muscle mass, age and gender. Cystatin-C (CysC) is a low molecular weight protein which is freely filtered through the glomerulus. It has been said to be as accurate as plasma creatinine and is independent of limitations derived from anthropometric parameters. CysC can also be determined through point of care devices which do not require the phlebotomy or experienced laboratory personnel for its use. There have also been correlations noted in CysC serum concentrations and cardiovascular risk assessment.
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    The effect of dossier farming on medicine registration in South Africa.
    (University of the Western Cape, 2020) Molokwane, Mmamaswa Flucia; Upton, Edward
    In this study, the researcher wanted to determine the effect of dossier farming in medicine registration in South Africa by comparing the number of generic registrations of products tendered for the government for the molecules enalapril, amlodipine and losartan, before and after innovator patent expiration and quantified the extent it is practiced and how it affected medicine registration backlog.
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    Risk based approach of post- approval changes in central America and Dominican republic, identifying opportunities for convergence with EMA and FDA
    (University of Western Cape, 2021) Vásquez, Ana Gabriela Trejos; Upton, Edward
    In Central American countries (Guatemala, El Salvador, Honduras, Nicaragua, Costa Rica and Panama) and Dominican Republic (DR) the approval timelines for major changes are described ranging from 12 to 18 months, these timelines are considerably extensive. Other countries or regions applying FDA post-approval change and EMA post-approval variation guidelines have timelines of 6 months or less (Hoath et al, 2016, Murray, 2016). The research aims to identify opportunities for alignment of the post-approval changes categories of Central America (CA) and Dominican Republic (DR) National Regulatory Agencies (NRA) with the riskbased categories of FDA and EMA as encouraged by the ICH. The FDA and EMA are considered reference authorities for many countries, as they are Stringent Authorities.