Browsing by Author "Salubi, Christiana Abimbola"

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    Heterogeneous vanadium Schiff base complexes in catalytic oxidation reactions
    (Growing Science, 2023) Salubi, Christiana Abimbola
    The chemistry of Schiff base has received remarkable attention in different applications, both organic synthesis and industries. Over the past few years many reports have been on the synthesis, characterization and application of vanadium Schiff base complexes. However, heterogeneous vanadium Schiff base catalysts are active for various oxidation reactions, making catalytic oxidation of hydrocarbons a great interest. This review summarizes the recent development of organic substrate oxidation with heterogeneous vanadium Schiff base catalysts.
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    Synthesis of new biguanide derivatives as potential antidiabetic drugs
    (University of the Western Cape, 2022) Salubi, Christiana Abimbola; Titinchi, Salam
    The main purpose of this study was to synthesize biguanide compounds with potential as antidiabetic drugs. All biguanide compounds possess antidiabetic properties by decreasing the blood glucose level. Hence, we embarked on the synthesis of a series of biguanides in a threestep reaction which involves synthesis of a Schiff base, reduction of the Schiff base to a secondary amine using sodium borohydride and lastly formation of substituted biguanide derivatives with amines (primary or secondary) and dicyandiamide.
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    Synthesis, in silico and antimicrobial activity study of substituted aromatic imines and their corresponding amines
    (Elsevier B.V., 2025) Abbo, Hanna; Holman, Darin Edward; Hendricks, Mohamed-Deen; Salubi, Christiana Abimbola; Keyster, Marshall; Titinchi, Salam
    The antimicrobial properties of Schiff bases and their corresponding amines were assessed by exploring the impact of substituent variations on these activities. The present study involved the synthesis of Schiff base compounds and their corresponding sec-amines, characterization, antibacterial testing, and molecular docking studies. These compounds featured diverse structural components, including alkyl chains, phenyl and methoxy groups. Three of the synthesized compounds are new, viz. N-[(2,3-dimethoxyphenyl) methylene]-1-propanamine (1), N-[(2,3-dimethoxyphenyl)methyl]-1-propanamine (2) and N-[(2,3-dimethoxyphenyl)methylene]-1-butanamine (3). The assessment of antibacterial properties targeted two strains recognized as opportunistic pathogens. Notably, all Schiff base compounds possessing the −C=N moiety exhibited good antibacterial activity against P. aeruginosa and P. agglomerans. Specifically, 1 and 3 demonstrated exceptional effectiveness against the tested bacterial strains, showcasing promising antibacterial capabilities. Furthermore, binding energy calculations revealed that compounds 1 and 3 exhibited binding energies of −3.9, −4.1, and −3.8, −3.9 kcal/mol with respect to P. agglomerans and P. aeruginosa candidate proteins, respectively. This underscores the strong interaction between the synthesized compounds and the bacterial strains, further supporting their potential as potent antimicrobial agents. P. aeruginosa and P. agglomerans were found to be sensitive to both compounds 1 and 3, as well as the standard control ampicillin. The MIC values for P. aeruginosa were 10 mM for 1, and 6 mM for 3. While for P. agglomerans, the MIC values were 6 mM for both 1 and 3.