Browsing by Author "Kirby-McCollough, Bronwyn"

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    Novel phages of healthy skin metaviromes from South Africa
    (Nature Publishing Group, 2018) van Zyl, Leonardo Joaquim; Abrahams, Yoonus; Stander, Emily Amor; Kirby-McCollough, Bronwyn; Jourdain, Roland; Clavaud, Cécile; Breton, Lionel; Trindade, Marla
    Recent skin metagenomic studies have investigated the harbored viral diversity and its possible influence on healthy skin microbial populations, and tried to establish global patterns of skin-phage evolution. However, the detail associated with the phages that potentially play a role in skin health has not been investigated. While skin metagenome and -metavirome studies have indicated that the skin virome is highly site specific and shows marked interpersonal variation, they have not assessed the presence/absence of individual phages. Here, we took a semi-culture independent approach (metaviromic) to better understand the composition of phage communities on skin from South African study participants. Our data set adds over 130 new phage species of the skin to existing databases. We demonstrated that identical phages were present on different individuals and in different body sites, and we conducted a detailed analysis of the structural organization of these phages. We further found that a bacteriophage related to the Staphylococcus capitis phage Stb20 may be a common skin commensal virus potentially regulating its host and its activities on the skin